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Therapeutic effects of crizotinib in EML4-ALK-positive patients with non-small-cell lung cancer / 南方医科大学学报
Journal of Southern Medical University ; (12): 753-757, 2015.
Article in Chinese | WPRIM | ID: wpr-355289
ABSTRACT
<p><b>OBJEVTIVE</b>To evaluate the therapeutic effects of different therapeutic regimens for non-small-cell lung cancer (NSCLC) with or without EML4-ALK rearrangement.</p><p><b>METHODS</b>Twenty-one ALK-positive and 50 ALK-negative NSCLC patients who received voluntarily EML4-ALK testing and 75 NSCLC patients without AL testing were enrolled in this study. The 3 groups of patients received different treatments, and the therapeutic effects, progression-free survival (PFS), and treatment-related adverse events were analyzed.</p><p><b>RESULTS</b>Crizotinib treatment obviously prolonged the PFS in EML4-ALK-positive patients with an objective response rate (OOR) of 61.9% and a median response duration of 16 months, which were significantly better than those in with ALK-negative patients and patients without ALK testing who received different second-line therapies.</p><p><b>CONCLUSION</b>Crizotinib is superior to platinum-based chemotherapy in NSCLC patients with ALK rearrangement. ALK rearrangement id not a modifier of the effect of chemotherapy regimens in NSCLC patients.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrazoles / Pyridines / Oncogene Proteins, Fusion / Carcinoma, Non-Small-Cell Lung / Disease-Free Survival / Therapeutic Uses / Drug Therapy / Lung Neoplasms Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrazoles / Pyridines / Oncogene Proteins, Fusion / Carcinoma, Non-Small-Cell Lung / Disease-Free Survival / Therapeutic Uses / Drug Therapy / Lung Neoplasms Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2015 Type: Article