Time Course of UV - Induced Immune Suppression of DNCB Contact Hypersensitivity in Guinea Pigs / 대한피부과학회지

ABSTRACT

The current experiment pursued the time course of UVB-induced immune suppression of DNCB contact hypersensitivity(CHS) in guinea pigs. Both group B and C, received suberythemal doses of UVB on days -3, -2, -1, 0 and -6, -5, -4, 3 respectively, showed marked suppressions of CHS (56.36p;and56.25p,). However, the recovery of CHS from the UVB-induced suppression started by group D(UVB on days -9, -8, -7, -6 67. 36%) and further extended to subsequent group E(UVB on days -12, -11, -10, -9 78.82%), Group F(UVB on days -15, -14, -13, -12 79.86%) and the final group G(UVB on days -18, -17, -16, -15 81. 94%) in which the recovery of CHS slightly exceeded the control (group A79. 86%).