Expression of helicase DDX41 in human dental pulp tissues and cells / 南方医科大学学报
Journal of Southern Medical University
;
(12): 587-590, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-355322
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of D-E-A-D-box polypeptide 41 (DDX41) in human dental pulp tissues and cells.</p><p><b>METHODS</b>The mRNA and protein expressions of DDX41 in human dental pulp cells were detected by RT-PCR and immunocytochemistry, and the expression of DDX41 in human dental pulp tissues was investigated by immunohistochemistry.</p><p><b>RESULTS</b>Strong expressions of DDX41 mRNA and protein were detected in dental pulp cells. In dental pulp tissues, DDX41 was expressed in the cytoplasm and nucleus of odontoblasts.</p><p><b>CONCLUSION</b>DDX41/STING-dependent TBK1-IRF3-IFN-β signaling pathway may play a role in innate immune responses of the dental pulp to caries and pulpitis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Immunohistochemistry
/
Signal Transduction
/
Cell Nucleus
/
Cells, Cultured
/
Cytoplasm
/
Dental Pulp
/
DEAD-box RNA Helicases
/
Metabolism
/
Odontoblasts
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2015
Type:
Article
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