Alpha-Tocopherol Transfer Protein (alpha-TTP): Insights from Alpha-Tocopherol Transfer Protein Knockout Mice
Nutrition Research and Practice
;
: 247-253, 2007.
Article
in English
| WPRIM
| ID: wpr-35555
ABSTRACT
Alpha-tocopherol transfer protein (alpha-TTP) is a liver cytosolic transport protein that faciliates alpha-tocopherol (alpha-T) transfer into liver secreted plasma lipoproteins. Genetic defects in alpha-TTP, like dietary vitamin E deficiency, are associated with infertility, muscular weakness and neurological disorders. Both human and alpha-TTP deficient (alpha-TTP-/-) mice exhibit severe plasma and tissue vitamin E deficiency that can be attenuated by sufficient dietary alpha-T supplementations. In this review, we summarize the literature concerning studies utilizing the alpha-TTP-/- mice. Levels of vitamin E in the alpha-TTP-/- mice do not appear to be directly related to the amounts of dietary alpha-T or to the levels of alpha-TTP protein in tissues. The alpha-TTP-/- mice appear to present a good model for investigating the specific role of alpha-T in tissue vitamin E metabolism. Furthermore, alpha-TTP-/- mice appear to be useful to elucidate functions of alpha-TTP beyond its well recognized functions of transferring alpha-T from liver to plasma lipoprotein fractions.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma
/
Vitamin E
/
Vitamin E Deficiency
/
Vitamins
/
Mice, Knockout
/
Muscle Weakness
/
Alpha-Tocopherol
/
Cytosol
/
Infertility
/
Lipoproteins
Limits:
Animals
/
Humans
Language:
English
Journal:
Nutrition Research and Practice
Year:
2007
Type:
Article
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