Correlation between VLA-4 integrin and hematopoietic cell migration / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 230-234, 2003.
Article
in English
| WPRIM
| ID: wpr-355676
ABSTRACT
To clarify the relationship between VLA-4 (CD49d) expression and hematopoietic cell migrating direction, mice were injected subcutaneously with diluted rhG-CSF for different times. The expressions of CD49d on Sca-1(+) cells were examined by flow cytometry. The relations between CD49d expression and Sca-1(+) cell enumerations were performed by statistical analysis. The results showed that with the administration of G-CSF, the expressions of CD49d in bone marrow (BM) and peripheral blood (PB) declined, meanwhile the number of Sca-1(+) cells in peripheral blood reached the peak in sharp contrast to BM nucleated cell number dropping on the seventh to ninth day. When CD49d expression rose again, the PB Sca-1(+) cells descended with the rising of BM nucleated cell number. In conclusion, VLA-4 mediates the hematopoietic cell adhesion to BM microenvironment. The regulation of CD49d expression may result in different migrating direction of hematopoietic cell between bone marrow and peripheral blood.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Time Factors
/
Blood
/
Bone Marrow Cells
/
Hematopoietic Stem Cells
/
Cell Count
/
Cell Movement
/
Granulocyte Colony-Stimulating Factor
/
Hematopoietic Stem Cell Mobilization
Limits:
Animals
Language:
English
Journal:
Journal of Experimental Hematology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS