The effect of SARS coronavirus on blood system: its clinical findings and the pathophysiologic hypothesis / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 217-221, 2003.
Article
in English
| WPRIM
| ID: wpr-355679
ABSTRACT
Severe acute respiratory syndrome (SARS) has recently recognized as a new human infectious disease. A novel coronavirus was identified as the causative agent of SARS. This report summarizes the hematological findings in SARS patients and proposes a hypothesis for the pathophysiology of SARS coronavirus related abnormal hematopoiesis. Hematological changes in patients with SARS were common and included lymphopenia (68% - 90% of adults; 100% of children, n = 10), thrombocytopenia (20% - 45% of adults, 50% of children), and leukopenia (20% - 34% of adults, 70% of children). The possible mechanisms of this coronavirus on blood system may include (1) directly infect blood cells and bone marrow stromal cells via CD13 or CD66a; and/or (2) induce auto-antibodies and immune complexes to damage these cells. In addition, lung damage in SARS patients may also play a role on inducing thrombocytopenia by (1) increasing the consumption of platelets/megakaryocytes; and/or (2) reducing the production of platelets in the lungs. Since the most common hematological changes in SARS patients were lymphopenia and immunodeficiency. We postulate that hematopoietic growth factors such as G-CSF, by mobilizing endogenous blood stem cells and endogenous cytokines, could become a hematological treatment for SARS patients, which may enhance the immune system against these virus.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Virology
/
Antigens, Differentiation
/
Antigens, CD
/
Cell Adhesion Molecules
/
CD13 Antigens
/
Severe Acute Respiratory Syndrome
/
Severe acute respiratory syndrome-related coronavirus
/
Allergy and Immunology
/
Hematologic Diseases
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Child
/
Humans
Language:
English
Journal:
Journal of Experimental Hematology
Year:
2003
Type:
Article
Similar
MEDLINE
...
LILACS
LIS