The relationship between dyslipemia and the polymorphism of angiotensin II type 1 receptor gene in hypertensive Kazakans of Xinjiang / 中华心血管病杂志
Chinese Journal of Cardiology
;
(12): 893-896, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-355870
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between dyslipidemia and the polymorphism of angiotensin II type 1 receptor (AT(1)R) gene A1166C in hypertensive Kazakans of Xinjiang area.</p><p><b>METHODS</b>Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the A1166C polymorphism of AT(1)R gene of 296 hypertensive and 198 normotensive Kazakans. Biochemical parameters were measured by autochemical emalyzer.</p><p><b>RESULTS</b>(1) The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [TC (4.91 +/- 1.19) mmol/L vs. (4.43 +/- 1.20) mmol/L; LDL-C (3.36 +/- 1.01) mmol/L vs. (2.94 +/- 1.30) mmol/L, P < 0.001). (2) In hypertension group, TC and LDL-C are related to A1166C polymorphism of AT(1)R gene and TC and LDL-C of AC carriers are significantly higher than AA carriers (P < 0.05).</p><p><b>CONCLUSION</b>The dyslipidemia is related to A1166C polymorphism of AT(1)R gene in hypertensive Kazakans.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
Receptor, Angiotensin, Type 1
/
Gene Frequency
/
Genetics
/
Genotype
/
Hypertension
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Cardiology
Year:
2008
Type:
Article
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