Preparation and in vitro release characteristics of pulsed-release tablets of Apocynum venetum / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1427-1430, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-356105
ABSTRACT
<p><b>OBJECTIVE</b>Using Apocynum venetum as a model drug to prepare pulsed-release tablets based on diffusion, swelling, osmotic pressure mechanism and to evaluate the release characteristics.</p><p><b>METHOD</b>The pulsatile release tablets were prepared by film coating methods using HPMC E5 and Eudragit The effect of formulation on pulsatile release of A. venetum was investigated.</p><p><b>RESULT</b>The pulsed-release tablet was prepared by a swelling layer coating which contains HPMC E5 and a controlled-release membrane containning Eudragit. The delayed release time of the tablets was (5.0 +/- 0.5) h.</p><p><b>CONCLUSION</b>The pulsatile release characteristics of A. venetum pulsatile release tablets were confirmed in vitro.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osmotic Pressure
/
Polymethacrylic Acids
/
Solubility
/
Tablets
/
Time Factors
/
In Vitro Techniques
/
Drugs, Chinese Herbal
/
Chemistry
/
Plant Leaves
/
Apocynum
Type of study:
Prognostic study
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2011
Type:
Article
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