Biomechanical properties of artery in spontaneously hypertensive rats after treating with tetrahydrobiopterin / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 325-328, 2009.
Article
in Zh
| WPRIM
| ID: wpr-356263
Responsible library:
WPRO
ABSTRACT
<p><b>AIM</b>To explore the effect of remodeling and biomechanical properties after chronic treating with tetrahydrobiopterin (BH4) in spontaneously hypertensive rats.</p><p><b>METHODS</b>The spontaneously hypertensive rat(SHR) were given with BH4 chronically. The opening angle in the zero-stress state , wall-to-lumen area ratios (W/L) of thoracic aorta and the relationship between pressure and diameter (P-D) of mesenteric artery were measured by computer image analysis in 4, 16, and 26 week-old respectively.</p><p><b>RESULTS</b>Treating with BH4 chronically from 4 weeks-old in SHR, there was a significant decrease in morphometric parameters of the thoracic aorta and an increase in the zero-stress state of opening angle of elastic artery. The P-D curve of mesenteric artery moved upward.</p><p><b>CONCLUSION</b>Treating with BH4 prevented the structure and function of artery from abnormal changing, including to attenuate the resistant vascular hypertrophy and recover the vascular elasticity and expansibility.</p>
Full text:
1
Index:
WPRIM
Main subject:
Arteries
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Rats, Inbred SHR
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Biomechanical Phenomena
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Biopterins
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Random Allocation
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Nitric Oxide Synthase
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Therapeutic Uses
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Drug Therapy
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Arteriolosclerosis
/
Hypertension
Limits:
Animals
Language:
Zh
Journal:
Chinese Journal of Applied Physiology
Year:
2009
Type:
Article