Cardiovascular effects of intermedin1-53 and its mechanism / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 308-311, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-356268
ABSTRACT
<p><b>AIM</b>The present study was designed to determined the cardiovascular effects of IMD1-53 in rats and its possible mechanism.</p><p><b>METHODS</b>Isolated rat hearts were perfused by Iangendorff mode, and ventricular function was measured after IMD1-53 perfusion. Meanwhere, we investigated the effects of IMDI) on arterial pressure after intravenous administration of IMD. And cAMP content was detected in rat ventricular and aortic tissues.</p><p><b>RESULTS</b>The results showed that perfusion with IMD significantly enhanced cardiac function and resulted in higher LVSP, +dp/dt(max) and -dp/dt(max) by 45%, 51% and 37%, respectively, compared with control and increased coronary infusion flow. The effects of IMD1-53 on cardiac function were antagonized by H-89, an inhibitor of PKA. The content of cAMP in the ventricular tissues after IMD perfusion was 131% higher than control. In addition, intravenous administration of IMD induced a potent decrease in arterial pressureand heart rate, and in aortic tissues, IMD incubation resulted in a 236% increase in cAMP content compared with control group.</p><p><b>CONCLUSION</b>The study reveals that IMD can increase cardiac function and decrease arterial pressure in rat and the effects may be related to cAMP pathway.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Blood Pressure
/
In Vitro Techniques
/
Neuropeptides
/
Cardiovascular Physiological Phenomena
/
Random Allocation
/
Ventricular Function
/
Rats, Sprague-Dawley
/
Cyclic AMP
/
Adrenomedullin
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2009
Type:
Article
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