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The lipid-regulating effect and safety of combined statin and bezafibrate therapy in acute coronary syndrome patients complicating with dyslipidemia / 中华心血管病杂志
Chinese Journal of Cardiology ; (12): 1006-1009, 2013.
Article in Chinese | WPRIM | ID: wpr-356468
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the lipid-regulating effect and safety of combined statin and bezafibrate therapy in acute coronary syndrome(ACS) patients complicating with dyslipedemia.</p><p><b>METHODS</b>One hundred and four hospitalized patients with established ACS and increased serum triglycerides (TG) levels and/or low serum levels of high density lipoprotein cholesterol (HDL-C) were selected. Except for conventional therapy, the patients were randomly divided into 2 groups control group (n = 52), treated with atorvastatin 20 mg qn or other statin equivalent to 20 mg atorvastatin; treatment group (n = 52), treated with the same dose statin plus bezafibrate 200 mg bid. The serum levels of total cholesterol (TC), TG, low-density lipoprotein cholesterol (LDL-C) and HDL-C were assessed before and after 6 and 12 weeks treatment, side effects and adverse events were recorded.</p><p><b>RESULTS</b>After 6 weeks treatment, the serum levels of TC, TG and LDL-C in two groups were significantly reduced compared to baseline (all P < 0.05), which were further declined after 12 weeks treatment, and the reduction was more significant in treatment group(29.8%, 38.0% and 36.1%, respectively) than in control group(14.7%, 9.8% and 26.7%, respectively) (all P < 0.05). After treatment, the serum levels of HDL-C in the two groups were significantly higher than the baseline levels, especially after 12 weeks treatment (all P < 0.05), and the elevations of HDL-C levels in control group and in treatment group were 19.3% and 24.2%, respectively, but there were no significant difference between the two groups (P > 0.05). After 12 weeks, the rates reaching to target goals of LDL-C, TG, HDL-C, and non-HDL-C levels in the treatment group (69.2%, 88.5%, 92.3%, 46.2% and 65.4%, respectively) were significantly higher than those in the control group (34.6%, 65.4%, 46.2%, 7.7% and 42.3%, respectively, all P < 0.05). No serious side effects were observed in the two groups during the treatment period.</p><p><b>CONCLUSION</b>The combined statin and bezafibrate treatment is safe and could increase the ratios of reaching target lipid levels in ACS patients complicating with increased TG and (or) decreased HDL-C.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrroles / Bezafibrate / Blood / Treatment Outcome / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Therapeutic Uses / Drug Therapy / Dyslipidemias / Acute Coronary Syndrome / Atorvastatin Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Cardiology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrroles / Bezafibrate / Blood / Treatment Outcome / Hydroxymethylglutaryl-CoA Reductase Inhibitors / Therapeutic Uses / Drug Therapy / Dyslipidemias / Acute Coronary Syndrome / Atorvastatin Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Cardiology Year: 2013 Type: Article