Influence of repeated platelet donation on megakaryopoiesis in donors / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 320-322, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-356568
ABSTRACT
To explore influence of platelet donation on donor's megakaryocytopoiesis, platelet counts and plasma concentrations of thrombopoietin (TPO), interleukin-3 (IL-3), IL-6 and nitric oxide (NO) were determined in 42 frequent platelet donors (undergoing plateletpheresis more than once a month for 24 months and their mean platelet yield of collection was 2.5 x 10(11)), in 62 limited platelet donors (undergoing plateletpheresis less than once a month for 24 months) after a donation-free period of > 5 weeks and in 40 whole blood donors who never undergoing plateletpheresis after a donation-free period of > 6 months. The results showed that the TPO levels was significantly lower in frequent platelet donors than in limited platelet donors (P < 0.01) and whole blood donors (P < 0.01). There were no significant differences between three groups in platelet counts, IL-3, IL-6 and NO. These findings suggest that the number of megakarocytes significantly increased in frequent platelet donors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Platelet Count
/
Thrombopoietin
/
Blood
/
Blood Donors
/
Megakaryocytes
/
Interleukin-6
/
Plateletpheresis
/
Interleukin-3
/
Cell Biology
/
Thrombopoiesis
Limits:
Adult
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2005
Type:
Article
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