Research progress in roles of high-risk human papillomavirus E2 protein / 病毒学报
Chinese Journal of Virology
;
(6): 201-207, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-356615
ABSTRACT
High-risk human papillomavirus (HPV) is the principal cause of various cancers including cervical cancer, anal cancer, vulvar cancer, and some head and neck cancers. In the viral life cycle, by interacting with both viral and host DNA and proteins, the HPV E2 protein plays a pivotal role in viral transcriptional regulation and DNA replication, and it is also associated with modification of various cellular processes, including host gene transcription, RNA processing, apoptosis, ubiquitination, and intracellular trafficking, to create a convenient environment for a replicative cycle of the virus and contribute to the HPV pathogenesis. Elucidating the roles of E2 protein throughout the viral life cycle will improve our understanding of the viral life cycle and pathogenesis and help us identify novel antiviral agents with therapeutic potential. This article reviews the research progress in the structure, roles, and activity of high-risk HPV E2 protein, particularly that of HPV-16.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
Gene Expression Regulation, Viral
/
Uterine Cervical Neoplasms
/
Oncogene Proteins, Viral
/
Papillomavirus Infections
/
DNA-Binding Proteins
/
Human papillomavirus 16
/
Genetics
/
Metabolism
Type of study:
Etiology study
Limits:
Animals
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2014
Type:
Article
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