Research progress in HIV auxiliary proteins counteracting host restriction factors / 病毒学报
Chinese Journal of Virology
;
(6): 84-90, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-356633
ABSTRACT
Identification and functional analyses of antiviral restriction factors in hosts have become hot research topics. Four HIV restriction factors, APOBEC3G, Trim5alpha, Tetherin, and SAMHD1, have been identified in recent years. By encoding auxiliary proteins, lentiviruses can counteract host restriction factors. For example, the auxiliary proteins Vif, Vpu, and Vpx of HIV antagonize APOBEC3G, Tetherin, and SAMHD1, respectively. Furthermore, these auxiliary proteins enable the entry of HIV into host cells and influence the replication and pathogenicity of HIV. In this paper, we review the research progress in the functions of the three HIV auxiliary proteins that can antagonize the host restriction factors.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Viral Proteins
/
HIV
/
Host-Pathogen Interactions
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2014
Type:
Article
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