Progress on mechanism of cell apoptosis induced by rubella virus / 病毒学报
Chinese Journal of Virology
;
(6): 578-582, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-356663
ABSTRACT
Rubella virus (RV), a member of the family Togaviridae, can induce apoptosis of host cells in vitro. Protein kinases of the Ras-Raf-MEK-ERK pathway and PI3K-Akt pathway play essential roles in virus multiplication, cell survival and apoptosis. Proteins p53 and TAp63 that bind to specific DNA sequences stimulate Bax in a manner to produce functional pores that facilitate release of mitochondrial cytochrome c and downstream caspase activation. In this review, the molecular mechanisms of RV-induced cell apoptosis, including RV-infected cell lines, pathological changes in cell components and apoptosis signaling pathways are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Rubella
/
Rubella virus
/
Virology
/
Apoptosis
/
Mitogen-Activated Protein Kinases
/
MAP Kinase Signaling System
/
Genetics
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Virology
Year:
2013
Type:
Article
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