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Progress on mechanism of cell apoptosis induced by rubella virus / 病毒学报
Chinese Journal of Virology ; (6): 578-582, 2013.
Article in Chinese | WPRIM | ID: wpr-356663
ABSTRACT
Rubella virus (RV), a member of the family Togaviridae, can induce apoptosis of host cells in vitro. Protein kinases of the Ras-Raf-MEK-ERK pathway and PI3K-Akt pathway play essential roles in virus multiplication, cell survival and apoptosis. Proteins p53 and TAp63 that bind to specific DNA sequences stimulate Bax in a manner to produce functional pores that facilitate release of mitochondrial cytochrome c and downstream caspase activation. In this review, the molecular mechanisms of RV-induced cell apoptosis, including RV-infected cell lines, pathological changes in cell components and apoptosis signaling pathways are summarized.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Rubella / Rubella virus / Virology / Apoptosis / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Genetics / Metabolism Limits: Humans Language: Chinese Journal: Chinese Journal of Virology Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Rubella / Rubella virus / Virology / Apoptosis / Mitogen-Activated Protein Kinases / MAP Kinase Signaling System / Genetics / Metabolism Limits: Humans Language: Chinese Journal: Chinese Journal of Virology Year: 2013 Type: Article