Effects of Siwu decoction on bone marrow protein expression of blood deficiency mice induced by cyclophosphamide / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the effects of Siwu decoction on protein expression of blood deficiency mice induced by cyclophosphamide (CIX) and discuss the possible molecular mechanism on blood enriching function of Siwu decoction.</p><p><b>METHOD</b>Blood deficiency mice were established by injecting ip with 250 mg x kg(-1) CTX. Proteomic technologies were applied to identify the different protein.</p><p><b>RESULT</b>Siwu decoction could restore the changes of 12 up-regulated and 3 down-regulated proteins in bone marrow of blood deficiency mice induced by cyclosphosphamide.</p><p><b>CONCLUSION</b>Siwu decoction could effect expression of proteins which functions including apoptosis, proliferation and differentiation of the haematopoietic stem/progenitor cell. The regulation in the molecular level might be the mechanism of stimulating hematopoiesis in bone marrow fo siwu decocetion.</p>