A chromatographic fingerprinting-based approach to evaluating the stability of production process of traditional Chinese medicine / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1151-1162, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-356720
ABSTRACT
<p><b>OBJECTIVE</b>To study a new method for the evaluation of the stability of production process of Traditional Chinese Medicines (TCM) based on chromatographic fingerprinting.</p><p><b>METHOD</b>Taking the extraction process of Red Ginseng for example, the fingerprints of extracts produced with fluctuating processing factors, i.e. ratio of solvent to liquid, solvent concentration, extraction durations and extraction times, were acquired. Meanwhile, the similarity of fingerprinting based on Euclidean distance was calculated and each fingerprint was fitwith cubic spline.</p><p><b>RESULT</b>Similarities of fingerprints of the extracts responded to the fluctuation of processing factors, and it showed that taking similarity as index, quantitative relation between chromatographic fingerprints and processing factors could be established.</p><p><b>CONCLUSION</b>The method proposed in the paper was able to describe the quality of products resulting from fluctuating conditions in extracting process, and therefore, can be developed as a practicable strategy to evaluate the stability Traditional Chinese Medicines in production process.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plants, Medicinal
/
Quality Control
/
Solvents
/
Drugs, Chinese Herbal
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Technology, Pharmaceutical
/
Ginsenosides
/
Drug Stability
/
Evaluation Studies as Topic
Type of study:
Diagnostic study
/
Evaluation studies
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2006
Type:
Article
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