Constituents in the alkaloid fraction of Kushen decoction / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the chemical constituents of the alkaloid fraction of Kushen decoction.</p><p><b>METHOD</b>Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods.</p><p><b>RESULT</b>Eight compounds were isolated and identified as matrine (I), sophoridine (II), sophocarpine (III), sophoramine (IV), oxymatrine (V), oxysophocarpine (VI), aloperine (VII) and sparteine (VIII).</p><p><b>CONCLUSION</b>All these compounds were isolated from Kushen decoction for the first time. Aloperine was found firstly in Sophora flavescens, or Scutellaria baicalensis, or Rehmannia glutinosa which constituted Kushen decoction.</p>