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Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population / 南方医科大学学报
Journal of Southern Medical University ; (12): 468-471, 2014.
Article in Chinese | WPRIM | ID: wpr-356897
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine- inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B.</p><p><b>METHODS</b>A total of 233 Chinese Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B.</p><p><b>RESULTS</b>The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05).</p><p><b>CONCLUSION</b>CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / Hepatitis B, Chronic / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Alleles / Suppressor of Cytokine Signaling Proteins / Gene Frequency / Genetics / Genotype Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Case-Control Studies / Hepatitis B, Chronic / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Asian People / Alleles / Suppressor of Cytokine Signaling Proteins / Gene Frequency / Genetics / Genotype Type of study: Observational study / Risk factors Limits: Adult / Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article