Association between CISH polymorphisms and susceptibility to chronic hepatitis B in Chinese Han population / 南方医科大学学报
Journal of Southern Medical University
;
(12): 468-471, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-356897
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokine- inducible src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B.</p><p><b>METHODS</b>A total of 233 Chinese Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study. The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic hepatitis B.</p><p><b>RESULTS</b>The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference between the patients and healthy controls (P>0.05).</p><p><b>CONCLUSION</b>CISH rs414171 is not significantly associated with the susceptibility to chronic hepatitis B in Chinese Han population.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Hepatitis B, Chronic
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Asian People
/
Alleles
/
Suppressor of Cytokine Signaling Proteins
/
Gene Frequency
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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