Effect of interleukin-1β on expressions of activin A and its related factors in cultured endometrial stromal cells from patients with endometriosis / 南方医科大学学报
Journal of Southern Medical University
;
(12): 410-413, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-356910
ABSTRACT
<p><b>OBJECTIVE</b>To study the effect of interleukin-1β (IL-1β) on the expressions activin A, follistatin, and cripto in cultured human endometrial stromal cells (HESCs) form patients with endometriosis.</p><p><b>METHODS</b>Cultured HESCs were stimulated with 250, 500, and 750pg/ml IL-1β, and the mRNA and protein expressions of activin A, follistatin, and cripto were assayed using real-time reverse transcriptase-polymerase chain reaction and enzyme-linked immunosorbent assay.</p><p><b>RESULTS</b>IL-1β treatment caused significant dose-dependent increments of the mRNA and protein expressions of activin A and follistatin and of the mRNA expression of cripto in cultured HESCs.</p><p><b>CONCLUSION</b>IL-1β can affect the expressions of activin A, follistatin and cripto in HESCs from patients with endometriosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Cells, Cultured
/
Stromal Cells
/
Cell Biology
/
Activins
/
Endometriosis
/
Endometrium
/
Interleukin-1beta
/
Metabolism
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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