Correlation analysis between miR-124 rs531564 polymorphisms and susceptibility to cervical cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 210-213, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-356953
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between miR-124 rs531564 polymorphisms and the susceptibility to cervical cancer in Chinese Han women in Guangdong Province.</p><p><b>METHODS</b>The genotypes of miR-124 rs531564 polymorphism were determined using polymerase chain reaction-based ligase detection reaction (PCR-LDR) in 107 cervical cancer patients and 208 healthy female blood donors. The correlation between the polymorphism and the susceptibility to cervical cancer was evaluated using unconditional logistic regression analysis.</p><p><b>RESULTS</b>The incidence of HPV infection in the patients (93.1%) was much higher than that in the control subjects (16.8%, P<0.001), suggesting the importance of HPV infection as a critical risk factor for cervical cancer. The G allele of miR-124 rs531564 polymorphism in the cervical cancer patients was much less frequent than that in the controls (8.0% vs 15.1%, P=0.014), suggesting its possible role as a protective allele. Compared with those carrying CC genotype, individuals carrying the CG and GG genotypes showed a significantly reduced risk for cervical cancer (OR=0.47, 95% CI=0.26-0.88, P=0.017), and this protective role of the G allele was more prominent in older women (≥45 years old) (OR=0.28, 95% CI=0.10-0.76, P=0.012).</p><p><b>CONCLUSION</b>miR-124 rs531564 polymorphism may play a role in cervical cancer susceptibility in Chinese Han women, and G allele is associated with a reduced risk of cervical cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Case-Control Studies
/
Uterine Cervical Neoplasms
/
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
MicroRNAs
/
Genetics
/
Genotype
Type of study:
Observational study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2014
Type:
Article
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