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miR-520a regulates ErbB4 expression and suppresses proliferation and invasion of esophageal squamous cell carcinoma / 南方医科大学学报
Journal of Southern Medical University ; (12): 164-168, 2014.
Article in Chinese | WPRIM | ID: wpr-356962
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of miR-520a in regulation ErbB4 expression and the biological behavior of esophageal squamous cell carcinoma (ESCC).</p><p><b>METHODS</b>The role of miR-520a in regulating the expression of ErbB4 was investigated by Western blotting and luciferase reporter assay system. The effect of miR-520a on the proliferation and invasion of ESCC cells was detected by MTT and Transwell invasion assay, respectively.</p><p><b>RESULTS</b>Western blotting and luciferase reporter assay revealed that miR-520a down-regulated the expression of ErbB4 in vitro. miR-520a significantly inhibited the proliferation and suppressed the invasion of ESCC cell line Eca109.</p><p><b>CONCLUSION</b>miR-520a regulates the expression of ErbB4 and suppresses the proliferation and invasion of ESCC cells in vitro, suggesting its role as a tumor suppressor.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Esophageal Neoplasms / Carcinoma, Squamous Cell / Gene Expression Regulation, Neoplastic / Cell Movement / MicroRNAs / Cell Line, Tumor / Cell Proliferation / Receptor, ErbB-4 / Metabolism Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Esophageal Neoplasms / Carcinoma, Squamous Cell / Gene Expression Regulation, Neoplastic / Cell Movement / MicroRNAs / Cell Line, Tumor / Cell Proliferation / Receptor, ErbB-4 / Metabolism Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2014 Type: Article