Advances in researches on lactate dehydrogenase-C4 isozyme / 中华男科学杂志
National Journal of Andrology
;
(12): 607-610, 2003.
Article
in Chinese
| WPRIM
| ID: wpr-357125
ABSTRACT
Lactate dehydrogenase-C4 isozyme has been widely studied as the sperm-specific antigen in the research of the contraceptive vaccine. Developmental and testis-specific expression of the LDH-C gene requires mechanisms for activation in germ cells and repression in somatic cells. LDH-C promoter, several transcription factors and methylation of CpG dinucleotides have been proved of governing action on LDH-C gene transcription. The strategy is to induce antibodies in the female reproductive tract against LDH-C antigens at a sufficient level to block fertilization. Chemically modified LDH-C4 offers a potential application in the induction of infertility of homologous species in marked contrast to native LDH-C4. In addition, advances are being made in researches on the male contraceptive vaccine and synthetic peptide immunocontraceptive.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Papio
/
Spermatozoa
/
Transcription, Genetic
/
Vaccines, Contraceptive
/
Allergy and Immunology
/
Genetics
/
Isoenzymes
/
L-Lactate Dehydrogenase
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2003
Type:
Article
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