Origin of Hematopoietic Stem Cells in Bone Marrow--Endothelial to Hematopoietic Transition (EHT)? / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 866-870, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357256
ABSTRACT
In contrast to primitive hematopoiesis, during embryonic definitive hematopoiesis, it has been demonstrated that multilineage hematopoietic stem/progenitor cells (HSPCs) arise from hemogenic endothelium, and the endothelial to hematopoietic transition (EHT) exists within the yolk sac, placenta, AGM, mouse head vascular and extraembryonic vessels. However, whether hemogenic endothelial cells contribute to blood cell development at other sites of definitive hematopoiesis, including fetal liver and bone marrow, remains largely unknown. Recently, more and more researches showed that hematopoiesis within bone marrow had a close relationship with vascular endothelium development, too. This review summarizes the mechanism of EHT during embryo development, and discuss whether EHT exists in adult hematopoiesis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Placenta
/
Yolk Sac
/
Bone Marrow
/
Hematopoietic Stem Cells
/
Endothelium, Vascular
/
Cell Differentiation
/
Endothelial Cells
/
Embryonic Development
/
Endothelium
/
Hemangioblasts
Limits:
Animals
/
Pregnancy
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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