Correlation of WT1 and VEGF Expression with Angiogenesis in Bone Marrow Biopsies of Multiple Myeloma Patients / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 733-736, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357281
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship of WT1 and VEGF expression with angiogenesis in bone marrow biopsies of multiple myeloma patients.</p><p><b>METHODS</b>VEGF, WT1 expression and microvessel density (MVD) of 62 cases of multiple myeloma and 10 normal bone marrow tissue were detected by in situ hybridization and immunohistochemistry SP method.</p><p><b>RESULTS</b>Microvessel density (MVD) of the control group was (45±6)/visual field, and while MVD of the multiple myeloma group was (84±26)/sight, and statistical analysis showed that MVD in multiple myeloma group was significantly higher than that in control group (P<0.05); in 62 cases of multiple myeloma the VEGF positive rate was 51.6% (32/62), and MVD in VEGF-positive group was significantly higher than that in the negative group (P<0.05). WT1 positive rate was 30.6% (19/62), and MVD in WT1-positive group was significantly higher than that in the negative group (P<0.05). And statistical analysis showed that WT1 expression significantly correlated with VEGF expression (P<0.05).</p><p><b>CONCLUSION</b>WT1 high expression of multiple myeloma bone tissue can up-regulate VEGF expression and promote angiogenesis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biopsy
/
Bone Marrow
/
WT1 Proteins
/
Vascular Endothelial Growth Factor A
/
Multiple Myeloma
/
Neovascularization, Pathologic
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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