Establishment of Human Acute B-Lymphoblastic Leukemia--NOD/SCID Xenotransplant Mouse Model / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 623-626, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357303
ABSTRACT
<p><b>OBJECTIVE</b>To establish human B-acute lymphoblastic leukemia NOD/SCID mouse model.</p><p><b>METHODS</b>The unirradiated mice aged 4-5 weeks were injected with Nalm-6 cells via the tail vein. Successful transplantation was assessed by the general state, bone marrow smear and histopathologic examination.</p><p><b>RESULTS</b>After 15 days of injection with Nalm-6 cells, the NOD/SCID mice displayed the morbidily with lethargy, hind limb paralysis, hunched back and lossing weight. The infiltration of leukemia cells could be observed in bone marrow and spleen sections.</p><p><b>CONCLUSION</b>Systemic B lineage acute leukemia animal mode1 has been successfully established in the NOD/SCID mice, which is a useful tool for studying pathogenesis of leukemia and guiding clinical chemotherapy regimens.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
Bone Marrow
/
Mice, SCID
/
Mice, Inbred NOD
/
Disease Models, Animal
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Neoplasm Transplantation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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