Application of Chimeric Antigen Receptor-Modified CAR-T/NK Cells to Treatment of Multiple Myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 568-572, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357314
ABSTRACT
Chimeric antigen receptor(CAR) is a synthesized transmembrane protein, which redirects the modified cells through specific or associated antigen on tumor cells. CAR-modified T/NK cells, especially CAR-T cells, are a new tool of rapidly developing of adoptive immunotherapy of tumor in recent years, they give T/NK cells the targeting cytotoxic activity and can overcome the tumor immunosuppressive microenvironment and break the state of the host immune tolerance. CAR combines the single-chain antibody to tumor-associated antigen with T/NK cells' activated motifs, giving T/NK cells' tumor targeting activity, so enhancing their cytotoxic activity and lasting the vitality by gene transduction. In this article the CAR development, comparison of CAR-T and CAR-NK cells, surface markers on MM cells and use of CAR in MM, and CAR perspectives are summarized.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Killer Cells, Natural
/
Lymphocyte Activation
/
Receptors, Antigen
/
T-Lymphocytes
/
Immunotherapy, Adoptive
/
Cell Line, Tumor
/
Multiple Myeloma
/
Antigens, Neoplasm
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2015
Type:
Article
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