Phase II study of docetaxel plus epirubicin versus docetaxel plus cisplatin as first-line chemotherapy for advanced breast cancer / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 541-544, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-357378
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and safety of combination of docetaxel plus epirubicin (TE) versus docetaxel plus cisplatin (TP) as first-line chemotherapy for locally advanced or metastatic breast cancer.</p><p><b>METHODS</b>Eighty-eight patients were randomized into two groups with a ratio of 21, either to receive TE or TP regimen. The patients received docetaxel 75 mg/m2 plus epirubicin 60 mg/m2 (TE group) or docetaxel 75 mg/m2 plus cisplatin 75 mg/m2 (TP group) administrated intravenously. Both regimens were once repeated 3 weeks later. The efficacy, time to progression and safety were evaluated at the end of the second cycle.</p><p><b>RESULTS</b>Complete response was achieved in 5% of TE group and 3.6% of TP. Overall (complete plus partial) response rates in TE and TP group were 48.3% and 60.7%, respectively (P = 0.2788). Disease control rates (CR + PR + SD) for TE and TP groups were 83.6% and 80%, respectively (P = 0.4899). The median time to progression (TTP) was 10 months for TE versus 8 months for TP groups (P = 0.7119). The major grade III or IV toxicities were neutropenia (66.7% in TE; 53.6% in TP, P = 0.2373); and alopecia (30.0% in TE; 10.7% in TP, P = 0.0508).</p><p><b>CONCLUSION</b>Both TE and TP regimens as first-line chemotherapy were similarly effective, safe and tolerable in the treatment for locally advanced or metastatic breast cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Remission Induction
/
Breast Neoplasms
/
Epirubicin
/
Antineoplastic Combined Chemotherapy Protocols
/
Prospective Studies
/
Cisplatin
/
Taxoids
/
Therapeutic Uses
/
Drug Therapy
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2008
Type:
Article
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