Multicenter phase II clinical trial of uroacitides injection in the treatment for advanced malignant tumors / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 534-537, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-357380
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the efficacy, safety and the life quality improvement of uroacitides injection in the treatment for patients with advanced malignant tumors.</p><p><b>METHODS</b>A total of 160 patients with advanced stage cancers were enrolled into this multicenter, open and non-randomized phase II clinical trial, including cancers of the lung (33 cases), liver (45 cases), breast (17 cases), esophagus (11 cases), stomach (18 cases), colon (19 cases), pancreas (3 cases) and kidney (4 cases), and glioma (10 cases). Uroacitides was administrated in a dose of 300 ml daily via the superior vena cava catheter for consecutive 4-8 weeks.</p><p><b>RESULTS</b>Of the 160 patients, 21 dropped out and one patient died during the trial. Efficacy could be evaluated in 138 patients and safety in 160. The total objective response rate (ORR, CR + PR)) and tumor control rate (CR + PR + MR + SD) of the 138 evaluable patients were 5.8% and 65.2%, respectively. Clinical benefit response (CBR) rate was 57.2%. Major adverse effects were grade I - II and reversible nausea/vomiting (21.9%) and pain (6.3%).</p><p><b>CONCLUSION</b>Uroacitides injection is effective in the control for various kinds of advanced cancers with mild, reversible and tolerable adverse effects, and can also improve the patient's quality of life. It is worth being studied further.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Peptides
/
Phenylacetates
/
Quality of Life
/
Vomiting
/
Blood
/
Remission Induction
/
Breast Neoplasms
/
Catheterization, Central Venous
/
Colorectal Neoplasms
Type of study:
Controlled clinical trial
Limits:
Humans
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2008
Type:
Article
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