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Preliminary study of biweekly regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer / 中华肿瘤杂志
Chinese Journal of Oncology ; (12): 389-391, 2008.
Article in Chinese | WPRIM | ID: wpr-357415
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of a biweekly DOF regimen consisting of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin for advanced gastric cancer.</p><p><b>METHODS</b>The biweekly DOF regimen was administered in 37 advanced gastric cancer patients. Docetaxel, oxaliplatin and leucovorin were given intravenously at a dose of 35 mg/m2, 85 mg/m2 and 200 mg/m2 for 1 h, 2 h and 2 h on D1, respectively, and 5-Fu was administered as continuous intravenous infusion for 48 h at a dose of 1500 mg/m2 on D1 and D2. This regimen was repeated every 2 weeks. The efficacy and toxicity were evaluated after completion of 3 cycles at least.</p><p><b>RESULTS</b>The overall response rate (RR) of this series was 67.6%, complete response rate and partial response rate were 27.0% and 40.5%, respectively. The time to progression (TTP) was 9.2 months, and median survival time (MST) was 13.7 months. The RRs of 11 chemotherpy-naïve patients and 26 patients pre-treated with chemotherapy were 81.8% and 61.5%, respectively.</p><p><b>CONCLUSION</b>Our preliminary results showed that this biweekly combination regimen of docetaxel, oxaliplatin, 5-fluorouracil and leucovorin is effective and tolerable for advanced gastric cancer. However, further investigation of this regimen is mandatory.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Organoplatinum Compounds / Pathology / Stomach Neoplasms / Vomiting / Remission Induction / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Leucovorin / Follow-Up Studies / Adenocarcinoma, Mucinous Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2008 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Organoplatinum Compounds / Pathology / Stomach Neoplasms / Vomiting / Remission Induction / Adenocarcinoma / Antineoplastic Combined Chemotherapy Protocols / Leucovorin / Follow-Up Studies / Adenocarcinoma, Mucinous Type of study: Observational study / Prognostic study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Oncology Year: 2008 Type: Article