The drug release properties of poly (acrylamide-co-itaconate-vinylbenzylglycosylallylamide) hydrogels / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 603-606, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-357642
ABSTRACT
Sugar-containing monomer vinylbenzylglycosylallyamide (VBG) was synthesized by vinylbenzyl amine and delta-gluconolactone in dimethylformamide(DMF) solution. The sugar-based hydrogel was prepared by free radical crosslinking copolymerization of VBG, itaconic acid (IA) and acrylamide (AM). The release properties of Aspirin from xerogels matrices and from hydrogel in different pH solutions and different concentration NaCl solutions were studied respectively. The release mechanism of Aspirin was further confirmed by evaluating the n value in Peppas equation. The results indicated that the drug release increased with the increase of pH values and with the decrease of NaCl concentration.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Succinates
/
Acrylic Resins
/
Vinyl Compounds
/
Chemistry
/
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Hydrogel, Polyethylene Glycol Dimethacrylate
/
Delayed-Action Preparations
/
Hydrogen-Ion Concentration
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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