Pilot study of a cell membrane like biomimetic drug-eluting coronary stent / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 599-602, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-357643
ABSTRACT
A novel bioinspired phospholipid copolymer has been synthesized by the radical polymerization of poly2-Methacryloyloxyethylphosphorylcholine (MPC), stearyl methacrylate (SMA), hydroxypropyl methacrylate (HPMA) and trimethoxysilylpropyl methacrylate (TSMA). Contact angle results indicated that the coating surface rearranged to get a more hydrophilic surface at the polymer/water interface. The membrane mimic phosphorylcholine coating surface could resist the platelet adhesion and prolong plasma recalcification time significantly. Rapamycin was used as model drugs to prepare drug-eluting coating. The animal experiments showed that this novel drug-eluting stent could effectively prevent the phenomena of restenosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phosphorylcholine
/
Polymers
/
Prosthesis Design
/
Swine
/
Swine, Miniature
/
Materials Testing
/
Random Allocation
/
Angioplasty, Balloon, Coronary
/
Chemistry
/
Pilot Projects
Type of study:
Controlled clinical trial
Limits:
Animals
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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