An experimental study of energy controllable steep pulse in the treatment of rat with subcutaneous transplantive tumor / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 492-495, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-357667
ABSTRACT
This experimental study was designed to investigate the effects and the expressions of microvessel density (MVD), vascular endothelial growth factor (VEGF) on the transplanted tumor in the rat model with Walker-256 after energy controllable steep pulse(ECSP). The experiment revealed that the steep pulse electrical field has better effect on tumor, compared with the control. The positive cell staining intensity of VEGF in the control group was significantly higher than that in ECSP group (P < 0.05). The number of MVD in the tumor tissues of ECSP group was significantly lower than that of tumor control group (P < 0.05). These results showed that ECSP could inhibit the growth and angiogenesis of tumor and its pathway is to down-regulate the expression of VEGF possibly.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Carcinoma 256, Walker
/
Electric Stimulation Therapy
/
Rats, Wistar
/
Electroporation
/
Vascular Endothelial Growth Factor A
/
Electric Conductivity
/
Electromagnetic Fields
/
Metabolism
/
Methods
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article
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