BMP-2 gene carried by biodegradable scaffold and fibrinous gel for repairing segmental radial defect in rabbit / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 345-349, 2007.
Article
in Zh
| WPRIM
| ID: wpr-357701
Responsible library:
WPRO
ABSTRACT
Adenovirus carrying BMP-2 gene, after being mixed with fibrinous gel, was siphoned off on biodegradable scaffolds (PLA/PCL). The composite was used to repair 1.5 cm long radius defect in rabbits. Four methods were in use in the experiments: Ad-BMP-2 plus fibrinous gel and PLA/PCL (Group A), reconstructed hBMP-2 plus fibrinous gel and PLA/PCL (Group B), Ad-Lacz plus fibrinous gel and PLA/PCL (Group C), and fibrinous gel and PLA/PCL (Group D). Results showed that the defects treated in Group A were repaired with much more new bone regenerated, bridged earlier and stronger than those in Group B 12 weeks after operation. The defects treated in the other two groups could not attain osseous tissue healing. BMP-2 gene carried by biodegradable scaffold and fibrinous gel is easy to conduct and has very strong osteoinduction ability. It is really a good method to repair segmental bone defects.
Full text:
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Index:
WPRIM
Main subject:
Polyesters
/
Polymers
/
Radius Fractures
/
Therapeutics
/
Biocompatible Materials
/
Caprolactam
/
Genetic Therapy
/
Adenoviridae
/
Chemistry
/
Fracture Healing
Limits:
Animals
/
Humans
Language:
Zh
Journal:
Journal of Biomedical Engineering
Year:
2007
Type:
Article