bcl-2 Expression in Cutaneous T Cell Lymphoma / 대한피부과학회지
Korean Journal of Dermatology
;
: 1024-1031, 1998.
Article
in Korean
| WPRIM
| ID: wpr-35786
ABSTRACT
BACKGROUND:
The bcl-2 is an oncogene involved in tumorigenesis by blocking apoptosis, or programmed cell death and over-expression of bcl-2 protein has been reported in several malignant tumors such as lung cancer, basal cell carcinoma, breast cancer and malignant melanoma. However, there have been only a few studies about bcl-2 expression of cutaneous T cell lymphoma.OBJECTIVE:
The purpose of this study was to examine whether there is any difference in expression of bcl-2 between mycosis fungoides(MF), angiocentric T cell lymphoma, angioimmunoblastic T cell lymphoma, subcutaneous T cell lymphoma and anaplastic large cell lymphoma. We also evaluated the statistical significance between expression of bcl-2 and the prognosis of the diseases.METHODS:
Routine paraffin sections of formalin-fixed 36 tissues (14 MF, 7 angiocentric T cell lymphoma, 5 subcutaneous panniculitic T cell lymphoma, 2 anaplastic large cell lymphoma, 1 angioimmunoblastic T cell lymphoma, 1 unspecified peripheral T cell lymphoma, 2 small plaque parapsoriasis, 2 psoriasis and 2 lichen planus) were labelled with anti-bcl-2 monoclonal antibody using an avidin- biotin-peroxidase complex. Normal skin for bcl-2 served as negative controls.RESULTS:
The results were as follows. l. All cases of benign inflammatory diseases, small plaque parapsoriasis and patch stages of MF showed positive staining for bcl-2. Therefore, there were no differences in expression of bcl-2 among these diseases. 2. In the plaque and tumor stages of mycosis fungoides, statistically significancant differences in bcl-2 expression were not found during disease progression. 3. bcl-2 expression in peripheral T cell lymphoma (five in seven cases of angiocentric T cell lymphoma showed positive staining but all other peripheral T cell lymphoma was negative) decreased significantly (p0.05).CONCLUSION:
These results suggest that the loss of bcl-2 expression may play a significant role in progression of cutaneous T cell lymphoma except in MF and angiocentric T cell lymphoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Oncogenes
/
Paraffin
/
Parapsoriasis
/
Prognosis
/
Psoriasis
/
Skin
/
Breast Neoplasms
/
Carcinoma, Basal Cell
/
Lymphoma, T-Cell
/
Lymphoma, T-Cell, Cutaneous
Type of study:
Prognostic study
Language:
Korean
Journal:
Korean Journal of Dermatology
Year:
1998
Type:
Article
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