Research Progress of a Novel Pro-apoptosis Gene PNAS-4 in Gene Therapy and Its Molecular Mechanism Hypotheses / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1380-1384, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357863
ABSTRACT
PNAS-4 is a novel pro-apoptosis gene identified latetly. In recent years, there has been a large number of research reports on the basic studies about PNAS-4 in cancer gene therapy and gene therapy of PNAS-4 alone or combined with chemotherapy or radiotherapy manifested a good application prospect, but its molecular mechanisms to promote apoptosis is not clear yet. In this paper, recent research about PNAS-4 in cancer gene therapy is briefly reviewed, and recent hypotheses on its molecular mechanisms to promote apoptosis are especially elucidated. Based on its newly identified characteristics of structural domain, we made a point that PNAS-4 might regulate functions of some target protein related to apoptosis by deSumoylation as a new deSumoylating isopeptidase, and consequently promote apoptosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Genetic Therapy
/
Apoptosis
/
Apoptosis Regulatory Proteins
/
Sumoylation
/
Genetics
/
Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2015
Type:
Article
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