Research Progress on the Development and Regulation of Embryonic Hematopoietic Stem Cells / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1141-1145, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-357905
ABSTRACT
Hematopoietic stem cells (HSCs) are tissue specific stem cells that replenish all mature blood lineages during the lifetime of an individual. Hematopoietic cell clusters in the aorta of vertebrate embryos play a pivotal role in the formation of the adult blood system. Recently, people have learned a lot about the embryonic HSCs on their development and homing. During their differentiation, HSCs are regulated by the transcription factors, such as Runx1 and Notch signaling pathway, etc. MicroRNAs also regulate the self-renewal and differentiation of hematopoietic stem/progenitor cells on the post-transcriptional levels. Since the onset of circulation, the formation of HSCs and their differentiation into blood cells, especially red blood cells, are regulated by the hemodynamic forces. It would be of great significance if we could treat hematologic diseases with induced HSCs in vitro on the basis of fully understanding of hemotopoietic stem cell development. This review is focused on the advances in the research of HSCs' development and regulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Transcription Factors
/
Blood Cells
/
Hematopoietic Stem Cells
/
Signal Transduction
/
Cell Differentiation
/
Cell Biology
/
Embryonic Stem Cells
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2015
Type:
Article
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