Combining endometrium sampling device and SurePath preparation to screen for endometrial carcinoma: a validation study / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 648-653, 2015.
Article
in English
| WPRIM
| ID: wpr-357943
ABSTRACT
<p><b>BACKGROUND</b>The aim of this study was to compare specimen adequacy of SAP-1 provided for cytology with that of dilation and curettage (D & C) or hysteroscopy for histology, and evaluate the accuracy of combining endometrium sampling by SAP-1 and liquid-based cytology using SurePath preparation for screening endometrial carcinoma and its precursor.</p><p><b>METHODS</b>Endometrial specimens from women (n = 1514) with risk factors were obtained using an SAP-1 device for cytological analysis; histological samples were obtained from 375 of these women who underwent D & C or hysteroscopy. Cytological specimens were prepared to liquid-based smear using SurePath technology and stained by Papanicolaou. Histological samples were processed in routine pathology and stained by hematoxylin and eosin.</p><p><b>RESULTS</b>Adequate specimens for cytology were obtained from 1458/1541 patients (96.3%), while adequate samples for pathology were obtained from 285/375 patients (76%). However, for postmenopausal women, 1006 of 1045 cytology (86.3%) were adequate, 153 of 238 histology (64.3%) were adequate, it was easier to collect cytological specimens than histological specimens (P < 0.05). The accuracy of endometrial cytology for detecting endometrial carcinoma and its precursor was 92.4% (sensitivity, 73%; specificity, 95.8%; positive predictive value, 75%; and negative predictive value, 95.3%).</p><p><b>CONCLUSIONS</b>Endometrial cytology using SAP-1 sampling and SurePath preparation may be a reliable approach for screening patients with endometrial carcinoma and its precursor.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Specimen Handling
/
Biopsy
/
Endometrial Neoplasms
/
Cytodiagnosis
/
Diagnosis
/
Endometrial Hyperplasia
/
Methods
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
Chinese Medical Journal
Year:
2015
Type:
Article
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