Influence of Xinqin tablets on guinea-pig nasal hypersensitivity / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of Xinqin tablets on guinea-pig nasal hypersensitivity.</p><p><b>METHOD</b>2,4-Toluene Diisocyanate (TDI) was selected as antigen and used in nose to establish guinea-pig allergic rhinitis. The effects of Xinqin tablets on symptoms of nasal hypersensitivity in guinea-pigs, histamine content of nasal mucosa and activity of nitric oxide synthase (NOS) were examined.</p><p><b>RESULT</b>Xinqin tablets could significantly relieve the pathological symptoms of nasal hypersensitivity in guinea-pig, reduce histamine content of nasal mucosa and inhibit the activity of nitric oxide synthase.</p><p><b>CONCLUSION</b>Xinqin tablets have significant effect on nasal hypersensitivity, and prevent the occurrence of allergic rhinitis.</p>