Effects of Guanyu capsule on the behavior and cerebral cortex monoamine neurotransmitters in depressive model of olfactory bulb damage rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 782-785, 2005.
Article
in Chinese
| WPRIM
| ID: wpr-358109
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the behavioral changes and the levels of monoamine neurotransmitters in the anterior cortex in the olfactory bulb damage rats after being treated with Guanyu capsules (GYC).</p><p><b>METHOD</b>Open-field test and step-down passive avoidance test were used to observe the behavior in model rats. HPLC-ECD was used to analyze the influences of GYC on the levels of monoamine neurotransmitters.</p><p><b>RESULT</b>In the model rats, there was a characteristic hyperactivity in the Open-field and learning deficits in step-down passive avoidance (P < 0.01). The contents of 5-HT reduced, and the rate of DOPAC/DA increased significantly (P < 0.01). GYC 1.2, 0.6 g x kg(-1) could correct behavioral changes increase the contents of 5-HT, and decrease DOPAC/DA level (P < 0.01).</p><p><b>CONCLUSION</b>GYC can correct behavioral changes in rats model of olfactory bulb damage, and regulating 5-HT and DA metabolism in cortex is one of the antidepressive mechanisms of GYC.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Olfactory Bulb
/
Pathology
/
Pharmacology
/
Plants, Medicinal
/
Behavior, Animal
/
3,4-Dihydroxyphenylacetic Acid
/
Drugs, Chinese Herbal
/
Biogenic Monoamines
/
Dopamine
/
Random Allocation
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2005
Type:
Article
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