Epidermal growth factor receptor gene mutations and clinicopathologic correlation in 309 patients with non-small cell lung cancer / 中华病理学杂志
Chinese Journal of Pathology
; (12): 660-663, 2011.
Article
in Zh
| WPRIM
| ID: wpr-358270
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the epidermal growth factor receptor (EGFR) gene mutation profile and related clinicopathological features in Chinese patients with non-small cell lung carcinoma (NSCLC).</p><p><b>METHODS</b>Optimized oligonucleotide probe method was applied to detect EGFR mutations involving exons 18 - 21 using formalin fixed paraffin embedded tissue specimens of 309 NSCLC patients. The relationship between EGFR mutations and clinicopathological features were analyzed.</p><p><b>RESULTS</b>The overall EGFR mutation rate was 34% (105/309) in this study cohort. Mutation rates in male and female were 30.4% (56/184) and 39.2% (49/125), respectively. The mutation rate was higher in patients less than 60 years of age, non-smokers and adenocarcinoma subtype than in their counterparts (P<0.05), with the percentage of 40.5% (87/215), 40.2% (51/127), 38.8% (78/201), respectively. The EGFR mutation types included exon 18 G719X mutation (5.7%, 6/105), exon 19 deletion (39.0%, 41/105) and exon 21 L858R mutation (55.2%, 58/105). In large cell undifferentiated carcinomas and squamous cell carcinomas, EGFR mutation rates were 22.2% (58/105) and 3/14, respectively. The overall mutation rate of exon 18 was low, but the proportion of its mutation was higher in squamous and adenosquamous carcinomas than in adenocarcinomas.</p><p><b>CONCLUSIONS</b>There is a higher EGFR mutation rate in female, age of less than 60 years, non-smoker and adenocarcinoma among Chinese patients with NSCLC. Optimized oligonucleotide probe method is a sensitive and convenient method for the detection of EGFR mutations.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Adenocarcinoma
/
Smoking
/
Sex Factors
/
Exons
/
Age Factors
/
Carcinoma, Large Cell
/
Carcinoma, Adenosquamous
/
Carcinoma, Non-Small-Cell Lung
Limits:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Language:
Zh
Journal:
Chinese Journal of Pathology
Year:
2011
Type:
Article