Simultaneous treatment of asthma and allergic rhinitis in children with a nasally inhaled glucocorticosteroid / 中华儿科杂志
Chinese Journal of Pediatrics
;
(12): 544-547, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-358536
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy of a nasally inhaled corticosteroid (ICS) through a spacer with mask aiming at simultaneous treatment of allergic rhinitis and asthma in children and make an analysis on the costs.</p><p><b>METHOD</b>A total of 72 children with allergic rhinitis (AR) and asthma were randomized into two groups. Experimental group received budesonide inhaler (400 microg/d) through the nose using a spacer attached to a face mask, control group children orally inhaled budesonide dry powder (400 microg/d) plus a nasal spray of budesonide aquae (256 microg/d).</p><p><b>RESULT</b>The patients were observed for 12 weeks. The symptom scores of rhinitis of both experimental group and control group declined (F=6.529 and 7.014, all P<0.01), symptom scores of asthma in both group were also reduced (F=4.132 and 4.950, P<0.01). The pulmonary function PEF (L/min) in both groups continuously increased (F=2.750 and 3.282, P<0.05). But the clinical scores, PEF value and FEV1 all did not differ between the two groups at admission or at nearly all follow-up visits (P>0.05 for all). The proportion of dry nose was lower in experimental group than in the control group (5.6% vs. 19.4%), but the difference was not statistically significant. The cost in the experimental group was lower than that in the control group (P<0.01).</p><p><b>CONCLUSION</b>Nasal inhalation of ICS provides a therapeutic strategy for controlling AR and asthma in children, especially it result in higher compliance, lower costs, and fewer side effects.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Administration, Inhalation
/
Rhinitis, Allergic, Perennial
/
Prospective Studies
/
Costs and Cost Analysis
/
Therapeutic Uses
/
Drug Therapy
/
Economics
/
Glucocorticoids
/
Masks
Type of study:
Controlled clinical trial
/
Health economic evaluation
/
Observational study
Limits:
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Pediatrics
Year:
2009
Type:
Article
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