Effect of high mobility group box-1 protein on immune cells and its regulatory mechanism / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 548-554, 2012.
Article
in English
| WPRIM
| ID: wpr-358700
ABSTRACT
High mobility group box-1 protein (HMGB1), which is a nuclear protein, participates in chromatin architecture and transcriptional regulation. When released from cells, HMGB1 also plays a well-established role as a pro-inflammatory mediator during innate immune responses to injury. In the initial stage of injury, there is a release of large quantities of early pro-inflammatory mediators to initiate or perpetuate immune responses against pathogens, but this pro-inflammatory period is transient, and it is followed by a prolonged period of immune suppression. At present, several lines of evidences have suggested that HMGB1 is a late cytokine provoking delayed endotoxin morbidity, which may enhance the production of early proinflammatory mediators, and it can contribute potently to the activation of different immune cells and play a role in the development of host cell-mediated immunity. The biology of HMGB1 has been extensively studied as a pro-inflammatory cytokine of systemic inflammation, however, this review will attempt to provide a summary of the effects of HMGB1 on different immune cells and its regulatory mechanism in acute insults.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Cytokines
/
HMGB1 Protein
/
Allergy and Immunology
/
Immunity, Cellular
/
Inflammation
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Applied Physiology
Year:
2012
Type:
Article
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