Influence of S₃ electrical stimulation on gastrointestinal dysfunction after spinal cord injury in rabbits / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
; (6): 267-274, 2014.
Article
in En
| WPRIM
| ID: wpr-358850
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of electrical stimulation to sacral spinal nerve 3 (S₃ stimulation) on gastrointestinal dysfunction after spinal cord injury (SCI).</p><p><b>METHODS</b>Six rabbits were taken as normal controls to record their gastrointestinal multipoint biological discharge, colon pressure and rectoanal inhibitory reflex. Electrodes were implanted into S₃ in another 18 rabbits. Then the model of SCI was conducted following Fehling's method: the rabbit S₃ was clamped to induce transverse injury, which was claimed by both somatosensory evoked potential and motion evoked potential. Two hours after SCI, S₃ stimulation was conducted. The 18 rabbits were subdivided into 3 groups to respectively record their gastrointestinal electric activities (n=6), colon pressure (n=6), and rectum pressure (n=6). Firstly the wave frequency was fixed at 15 Hz and pulse width at 400 μs and three stimulus intensities (6 V, 8 V, 10 V) were tested. Then the voltage was fixed at 6 V and the pulse width changed from 200 μs, 400 μs to 600 μs. The response was recorded and analyzed. The condition of defecation was also investigated.</p><p><b>RESULTS</b>After SCI, the mainly demonstrated change was dyskinesia of the single haustrum and distal colon. The rectoanal inhibitory reflex almost disappeared. S₃ stimulation partly recovered the intestinal movement after denervation, promoting defecation. The proper stimulus parameters were 15 Hz, 400 μs, 6 V, 10 s with 20 s intervals and 10 min with 10 min intervals, total 2 h.</p><p><b>CONCLUSION</b>S₃ stimulation is able to restore the intestinal movement after denervation (especially single haustrum and distal colon), which promotes defecation.</p>
Full text:
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Index:
WPRIM
Main subject:
Physiology
/
Sacrum
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Spinal Cord Injuries
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Evoked Potentials, Motor
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Gastrointestinal Tract
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Disease Models, Animal
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Electric Stimulation
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Electrodes, Implanted
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Evoked Potentials, Somatosensory
Limits:
Animals
Language:
En
Journal:
Chinese Journal of Traumatology
Year:
2014
Type:
Article