New insights into the activation mechanism of store-operated calcium channels: roles of STIM and Orai / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 591-601, 2008.
Article
in English
| WPRIM
| ID: wpr-359376
ABSTRACT
The activation of Ca2+ entry through store-operated channels by agonists that deplete Ca2+ from the endoplasmic reticulum (ER) is a ubiquitous signaling mechanism, the molecular basis of which has remained elusive for the past two decades. Store-operated Ca2+-release-activated Ca2+ (CRAC) channels constitute the sole pathway for Ca2+ entry following antigen-receptor engagement. In a set of breakthrough studies over the past two years, stromal interaction molecule 1 (STIM1, the ER Ca2+ sensor) and Orai1 (a pore-forming subunit of the CRAC channel) have been identified. Here we review these recent studies and the insights they provide into the mechanism of store-operated Ca2+ channels (SOCCs).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Protein Binding
/
Calcium Channels
/
Calcium
/
Calcium Signaling
/
Membrane Proteins
/
Metabolism
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS