Arylamine N-acetyltransferases: a new inhibitor of apoptosis in HepG2 cells / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 701-706, 2008.
Article
in English
| WPRIM
| ID: wpr-359382
ABSTRACT
<p><b>OBJECTIVE</b>To explore how arylamine N-acetyltransferases (NATs) is related to cell apoptosis.</p><p><b>METHODS</b>NAT activity in apoptotic HepG2 cells was measured using high performance liquid chromatography (HPLC); the apoptosis rate of HepG2 cells acted upon by an NAT inhibitor was measured using flow cytometry.</p><p><b>RESULTS</b>NAT activity was lowered in apoptotic HepG2 cells; apoptosis rate induced by camptothecin (CAM) increased after inhibition of NAT activity in HepG2 cells.</p><p><b>CONCLUSION</b>NAT can inhibit apoptosis in HepG2 cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Arylamine N-Acetyltransferase
/
Camptothecin
/
Cells, Cultured
/
Apoptosis
/
Hepatocytes
/
Cell Biology
/
Dose-Response Relationship, Drug
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2008
Type:
Article
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