Sodium arsenite reduces severity of dextran sulfate sodium-induced ulcerative colitis in rats / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 341-350, 2008.
Article
in English
| WPRIM
| ID: wpr-359422
ABSTRACT
The histopathological features and the associated clinical findings of ulcerative colitis (UC) are due to persistent inflammatory response in the colon mucosa. Interventions that suppress this response benefit UC patients. We tested whether sodium arsenite (SA) benefits rats with dextran sulfate sodium (DSS)-colitis. The DSS-colitis was induced by 5% DSS in drinking water. SA (10 mg/kg; intraperitoneally) was given 8 h before DSS treatment and then every 48 h for 3 cycles of 7, 14 or 21 d. At the end of each cycle rats were sacrificed and colon sections processed for histological examination. DSS induced diarrhea, loose stools, hemoccult positive stools, gross bleeding, loss of body weight, loss of epithelium, crypt damage, depletion of goblet cells and infiltration of inflammatory cells. The severity of these changes increased in the order of Cycles 1, 2 and 3. Treatment of rats with SA significantly reduced this severity and improved the weight gain.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Time Factors
/
Body Weight
/
Colitis, Ulcerative
/
Dextran Sulfate
/
Treatment Outcome
/
Rats, Wistar
/
Sodium Compounds
/
Colitis
Type of study:
Prognostic study
Limits:
Animals
Language:
English
Journal:
Journal of Zhejiang University. Science. B
Year:
2008
Type:
Article
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