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Anticoagulant Ability and Heparinization of Decellularized Biomaterial Scaffolds / 生物医学工程学杂志
Journal of Biomedical Engineering ; (6): 594-598, 2015.
Article in Chinese | WPRIM | ID: wpr-359601
ABSTRACT
In order to enhance the anticoagulant properties of decellularized biological materials as scaffolds for tissue engineering research via heparinized process, the decellularized porcine liver scaffolds were respectively immobilized with heparin through layer-by-layer self-assembly technique (LBL), multi-point attachment (MPA) or end-point attachment (EPA). The effects of heparinization and anticoagulant ability were tested. The results showed that the three different scaffolds had different contents of heparin. All the three kinds of heparinized scaffolds gained better performance of anticoagulant than that of the control scaffold. The thrombin time (TT), prothrombin time (PT) and activated partial thromboplastin time (APTT) of EPA scaffold group were longest in all the groups, and all the three times exceeded the measurement limit of the instrument. In addition, EPA scaffolds group showed the shortest prepared time, the slowest speed for heparin release and the longest recalcification time among all the groups. The decellularized biological materials for tissue engineering acquire the best effect of anticoagulant ability in vitro via EPA heparinized technique.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Swine / Biocompatible Materials / Heparin / Chemistry / Tissue Engineering / Tissue Scaffolds / Liver / Anticoagulants Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Swine / Biocompatible Materials / Heparin / Chemistry / Tissue Engineering / Tissue Scaffolds / Liver / Anticoagulants Limits: Animals Language: Chinese Journal: Journal of Biomedical Engineering Year: 2015 Type: Article