Effect of testosterone on morphine withdrawal syndrome in rats / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 765-769, 2008.
Article
in English
| WPRIM
| ID: wpr-359912
ABSTRACT
<p><b>AIM</b>To determine whether testosterone is involved in morphine withdrawal syndrome (WS).</p><p><b>METHODS</b>In order to induce dependency, rats were treated with subcutaneous injection of morphine (days 1-2, 5 mg/kg; days 3-5, 7.5 mg/kg; days 6-8, 10 mg/kg), and after the last dose of morphine (day 8) WS was induced by intraperitoneal injection of naloxone (1 mg/kg). Wet dog shake (WDS), abdomen writhing (AW), and jumps (J) were recorded as indicators of WS.</p><p><b>RESULTS</b>The severity of WDS, AW, and J in male rats was greater than that in females. Accordingly, in 4-week castrated and flutamide-treated (10 mg/kg/day for 8 days, i.p.) male rats, WDS, AW, and J were significantly decreased compared to male control rats. Testosterone replacement therapy (10 mg/kg/day for 8 days, i.m.) in 4-week castrated rats restored the severity of WDS, AW, and J behaviors to the level of non-castrated male rats, whereas testosterone potentiated the WDS behavior in non-castrated male rats.</p><p><b>CONCLUSION</b>It can be concluded that testosterone might be effectively involved in morphine WS.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Substance Withdrawal Syndrome
/
Testosterone
/
Behavior, Animal
/
Severity of Illness Index
/
Orchiectomy
/
Rats, Wistar
/
Flutamide
/
Androgen Antagonists
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
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