Ex vivo antioxidant effects of D-004, a lipid extract from Roystonea regia fruits, on rat prostate tissue / 亚洲男科学杂志(英文版)
Asian Journal of Andrology
;
(6): 659-666, 2008.
Article
in English
| WPRIM
| ID: wpr-359924
ABSTRACT
<p><b>AIM</b>To investigate whether oral treatment with D-004, a lipid extract of the Cuban royal palm fruit, produces antioxidant effects in the prostate tissue of normal and testosterone (T)-treated rats.</p><p><b>METHODS</b>In our first experiment, normal rats were distributed into five groups one group treated with the vehicle and four groups treated with D-004 (100, 200, 400 or 800 mg/kg). In our second experiment, rats were randomized into five groups a negative control group and four T-injected groups. The latter were comprised of a positive control group treated with the vehicle, and three groups treated with D-004 (200, 400 or 800 mg/kg).</p><p><b>RESULTS</b>In normal rats, D-004 (100-800 mg/kg) inhibited significantly and dose-dependently iron-initiated malondialdehyde (MDA) accumulation in prostate homogenates (35.7%-80.0%) vs the controls. D-004 (200-800 mg/kg) significantly reduced baseline MDA and carbonyl groups in prostate homogenates of normal rats to approximately 80% and 50%, respectively, and totally (100%) in T-treated rats.</p><p><b>CONCLUSION</b>Oral treatment with D-004 reduced MDA and carbonyl groups dose-dependently and markedly in normal and T-injected rats. These findings show that D-004 given at doses effective to prevent prostate hyperplasia also produces antioxidant effects in the prostate tissue.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Prostate
/
Prostatic Hyperplasia
/
Plant Extracts
/
Administration, Oral
/
Rats, Wistar
/
Dose-Response Relationship, Drug
/
Malondialdehyde
/
Metabolism
/
Antioxidants
Limits:
Animals
Language:
English
Journal:
Asian Journal of Andrology
Year:
2008
Type:
Article
Similar
MEDLINE
...
LILACS
LIS